Nonsteroidal anti-inflammatory drugs (NSAID) are components of a drug group that alleviate pain, inflammation, fever and reduces blood clots. These drugs are the most prescribed medicines as they can provide pain relief in an instant. NSAID medicines are usually taken to alleviate the pain after surgery. Moreover, over-the-counter NSAID drugs are more accessible to purchase than medicines that require a prescription. But what is the safest NSAID to use? Based on research, naproxen is the safest anti-inflammatory drug that has fewer side effects.